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Antiviral Activity Of Porcine Interferon D.elta 8 Against Foot-And-Mouth D isease Virus In Vitro

文献类型： 外文期刊

作者： Li, SF; Shao, JJ; Zhao, FR; Gong, MJ; Xie, YL; Chang, HY; Zhang, YG

作者机构：

关键词： Type I interferon; Porcine interferon-delta; Antiviral activity; FMDV

期刊名称： INTERNATIONAL IMMUNOPHARMACOLOGY

ISSN： 1567-5769

年卷期： 2018 年 59 卷

页码：

收录情况： JCR（2021版）

摘要： Foot-and-mouth disease (FMD) is one of the most devastating diseases affecting livestock. Since vaccines fail to provide protection until seven days post-vaccination, the application of anti-viral molecules is imperative for suppressing the spread of FMDV prior to development of an adaptive immune response. Interferons (IFNs) are effective for the host to fight FMDV infections; however, a novel type I IFNs, interferon delta (IFN-delta), has not been investigated for their antiviral effects against this virus. Thus, this study investigated FMDV infection, upon pre- and post-treatment with PoIFN-delta 8. Real-time quantitative PCR was used to quantify the expression levels of IFN-stimulated genes (ISG5), including ISG15, OAS1, PKR, and Mx1. Results showed the PolFN-delta 8 lacking its signal sequence was efficiently expressed in Escherichia coh., and the purified recombinant PoIFN-delta 8 exerted a significantly protective effect against two different serotypes of FMDV in IBRS-2 cells. In addition, PoIFN-delta 8 induced the expression of IFN-stimulated genes. These findings highlight the significance of PoIFN-delta might serve as an antiviral agent for the prevention of FMDV in pigs and will stimulate the study of exploiting the potential biological functions of IFN-delta in the future.

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