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A Novel Type I Interferon, I.nterferon Alphaomega, Shows Antiviral A ctivity Against Foot-And-Mouth Disease Virus In Vitro

文献类型： 外文期刊

作者： Li, SF; Gong, MJ; Xie, YL; Shao, JJ; Zhao, FR; Zhang, YG; Chang, HY

作者机构：

关键词： Type I interferon; PoIFN-alpha omega; Foot and mouth disease virus; Interferon stimulated genes; Antiviral activity; IFN-mu

期刊名称： MICROBIAL PATHOGENESIS

ISSN： 0882-4010

年卷期： 2019 年 127 卷

页码：

收录情况： JCR（2021版）

摘要： Recently, a novel type I interferon alphaomega (IFN-alpha omega), also known as IFN-mu, was identified. However, the biological activity of IFN-alpha omega remain poorly understood. In this study, the porcine IFN-alpha omega (PoIFN-alpha omega) was expressed, purified, and its antiviral activities assessed by its ability to inhibit the cytopathic effect caused by FMDV on IBRS-2 cells. In addition, q-PCR was used to evaluate the expression of IFN-stimulated genes induced by PoIFN-alpha omega. It was found that PoIFN-alpha omega exerted effective antiviral activity against FMDV pre- and post-infection. Additionally, PoIFN-alpha omega induced the transcription of IFN-stimulated genes, including Mx1, ISG15, OAS1, and PKR genes. Our study reported a new indication of PoIFN-alpha omega as an effective anti-FMDV agent for the first time.

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