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Effects of Prevotella copri on insulin, gut microbiota and bile acids

文献类型： 外文期刊

作者： Gong J.;Zhang Q.;Hu R.;Yang X.;Fang C.;Yao L.;Lv J.;Wang L.;Shi M.;Zhang W.;Ma S.;Xiang H.;Zhang H.;Hou D.-X.;Yin Y.;He J.;Peng L.;Wu S.

作者机构：

关键词： bile acids;gut microbiota;insulin;Obesity;prevotella copri

期刊名称： Gut Microbes

ISSN： 1949-0976

年卷期： 2024 年 16 卷 1 期

页码：

收录情况： SCIE（2024版）

摘要： Obesity is becoming a major global health problem in children that can cause diseases such as type 2 diabetes and metabolic disorders, which are closely related to the gut microbiota. However, the underlying mechanism remains unclear. In this study, a significant positive correlation was observed between Prevotella copri (P. copri) and obesity in children (p = 0.003). Next, the effect of P. copri on obesity was explored by using fecal microbiota transplantation (FMT) experiment. Transplantation of P. copri. increased serum levels of fasting blood glucose (p < 0.01), insulin (p < 0.01) and interleukin-1β (IL-1β) (p < 0.05) in high-fat diet (HFD)-induced obese mice, but not in normal mice. Characterization of the gut microbiota indicated that P. copri reduced the relative abundance of the Akkermansia genus in mice (p < 0.01). Further analysis on bile acids (BAs) revealed that P. copri increased the primary BAs and ursodeoxycholic acid (UDCA) in HFD-induced mice (p < 0.05). This study demonstrated for the first time that P. copri has a significant positive correlation with obesity in children, and can increase fasting blood glucose and insulin levels in HFD-fed obese mice, which are related to the abundance of Akkermansia genus and bile acids. © 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.

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