数字农科院2.0

Evaluation of the protective efficacy of a recombinant adenovirus-vectored SARS-CoV-2 vaccine candidate for veterinary use

文献类型： 外文期刊

作者： Chong Wang; Zhiyuan Wen; Gongxun Zhong; Lei Shuai; Chen Wang; Qilong Liu; Chenyu Ren; Jinying Ge; Xijun Wang; Jinliang Wang; Renqiang Liu; Xianfeng Zhang; Yuntao Guan; Xijun He; Zhigao Bu

关键词： Veterinary vaccine; SARS-CoV-2; adenovirus vector; protective efficacy; animal models

期刊名称： Frontiers in Cellular and Infection Microbiology

ISSN： 2235-2988

年卷期： 2025 年

页码：

收录情况： SCIE（2025版）

摘要： Since 2019, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed a global health threat. Its high transmissibility and cross-species infectivity have disrupted public health systems and worldwide economies, with companion and agricultural animals, like cats and minks, showing high susceptibility. This study evaluated rAd5-S6P, a recombinant vaccine using an adenovirus type 5 vector expressing a modified SARS-CoV-2 spike protein, in murine, feline, and mink models. Results demonstrated that rAd5-S6P elicited a robust humoral immune response when administered via intramuscular, intranasal, and oral routes, which conferred complete protection in mice. In feline and mink models, immunization with rAd-S6P resulted in significantly reduced viral shedding after high-dose SARS-CoV-2 challenge, and no infectious virus was detected in any of the examined organs of minks. Collectively, rAd5-S6P exhibited protective efficacy across species, supporting its translational potential as a veterinary vaccine. These findings provide critical evidence for animal vaccination strategies to control SARS-CoV-2 circulation and reduce zoonotic transmission risks.

分类号：

  • 相关文献

[1]The Inhibitory Effect Of Mesenchymal S.tem Cells With Rad-Nk4 O n Liver Cancer. Cai, C, Hou, LL, Zhang, JS, Zhao, DD, Wang, ZL, Hu, HG, He, JS, Guan, WJ, Ma, YH. 2017

[2]Newcastle Disease Virus-Like Particles Containing T.he Brucella Bcsp31 Protein I nduce Dendritic Cell Activation And Protect Mice Against Virulent Brucella Challenge. Xu, XH, Ding, Z, Li, JD, Liang, JM, Bu, ZY, Ding, JX, Yang, YL, Lang, XL, Wang, XL, Yin, RF, Qian, J. 2019

[3]Generation, Safety And Immunogenicity Of A.n Actinobacillus Pleuropneumoniae Quintuple D eletion Mutant Slwo7 (Delta Apxic Delta Apxiic Delta Orf1 Delta Cpxar Delta Arca). Yuan, FY, Liu, JL, You, WJ, Bei, WC, Wang, CL, Zhao, J, Tian, YX, Liu, SG. 2018

[4]Protective Efficacy Of A High-Growth R.eassortant H1N1 Influenza Virus V accine Against The European Avian-Like H1N1 Swine Influenza Virus In Mice And Pigs. Ruan, BY, Wen, F, Gong, XQ, Liu, XM, Wang, Q, Yu, LX, Wang, SY, Zhang, P, Yang, HM, Shan, TL, Zheng, H, Zhou, YJ, Tong, W, Gao, F, Tong, GZ, Yu, H. 2018

[5]Expression Of Truncated Babesia Microti A.pical Membrane Protein 1 A nd Rhoptry Neck Protein 2 And Evaluation Of Their Protective Efficacy. Wang, GB, Efstratiou, A, Moumouni, PFA, Liu, MM, Jirapattharasate, C, Guo, HP, Gao, Y, Cao, SN, Zhou, M, Suzuki, H, Igarashi, I, Xuan, XN. 2017

[6]Evaluation Of Two Strains Of M.areles Disease Virus Serotype 1 For The Development Of Recombinant Vaccines Against Very Virulent Infectious Bursal Disease Virus. Li, K, Liu, YZ, Liu, CJ, Gao, L, Gao, YL, Zhang, YP, Cui, HY, Qi, XL, Zhong, L, Wang, XM. 2017

[7]A Safe And Molecular-Tagged Brucella C.anis Ghosts Confer Protection A gainst Virulent Challenge In Mice. Qian, J, Bu, ZY, Lang, XL, Yan, GM, Yang, YL, Wang, XR, Wang, XL. 2017

[8]Protective Efficacy Of A Novel R.ecombinant Marek'S Disease Virus V ector Vaccine Against Infectious Bursal Disease In Chickens With Or Without Maternal Antibodies. Li, K, Liu, YZ, Zhang, YP, Gao, L, Liu, CJ, Cui, HY, Qi, XL, Gao, YL, Zhong, L, Wang, XM. 2017

[9]Protective efficacy of an H5/H7 trivalent inactivated vaccine produced from Re-11, Re-12, and H7-Re2 strains against challenge with different H5 and H7 viruses in chickens. Lu Tong,Chen Hua-lan,Mao Sheng-gang,Li Yan-bing,Tian Guo-bin,Wu Jiao-jiao,Ma Shu-jie,Chen Xiao-han,Bao Hong-mei,Liu Jing-li,Shi Jian-zhong,Chen Pu-cheng,Zeng Xian-ying,Hu Jing-lei,Deng Guo-hua,Jiang Yong-ping,Guo Xing-fu,Pan Shu-xin,Liu Yan-jing. 2020

[10]Genetic and biological characteristics of the globally circulating H5N8 avian influenza viruses and the protective efficacy offered by the poultry vaccine currently used in China. Cui, Pengfei,Zeng, Xianying,Li, Xuyong,Li, Yanbing,Shi, Jianzhong,Zhao, Conghui,Qu, Zhiyuan,Wang, Yanwen,Guo, Jing,Gu, Wenli,Ma, Qi,Zhang, Yuancheng,Lin, Weipeng,Li, Minghui,Tian, Jingman,Wang, Dongxue,Xing, Xin,Liu, Yanjing,Pan, Shuxin,Zhang, Yaping,Bao, Hongmei,Liu, Liling,Tian, Guobin,Li, Chengjun,Deng, Guohua,Chen, Hualan. 2022

[11]Characterization, Pathogenicity And Protective Efficacy Of A Cell Culture-Derived Porcine Deltacoronavirus. Gao, X, Zhao, DH, Zhou, P, Zhang, LP, Li, MX, Li, WY, Zhang, YG, Wang, YL, Liu, XS. 2020

[12]A seven-gene-deleted African swine fever virus is safe and effective as a live attenuated vaccine in pigs. . 2020

[13]Generation And Evaluation Of An African Swine Fever Virus Mutant With Deletion Of The Cd2V And Uk Genes. Teklue, T, Wang, T, Luo, YZ, Hu, RL, Sun, Y, Qiu, HJ. 2020

[14]A Lipid Nanoparticle Encapsulated CPA-CTD mRNA Vaccine Provides Protection Against Clostridium perfringens -Driven Diseases. 贾琦,,相浩雨,,乐婷,,王晶,,常继涛,,王芳,,孙超,,太万博,,姜志刚,,尹鑫. 2025

[15]Roles of the polybasic furin cleavage site of spike protein in SARS-CoV-2 replication, pathogenesis, and host immune responses and vaccination. Hossain, Md Golzar,Tang, Yan-dong,Akter, Sharmin,Zheng, Chunfu. 2021

[16]Animal coronaviruses and SARS-CoV-2. Zhang Guangzhi,Li Bin,Yoo Dongwan,Qin Tong,Zhang Xiaodong,Jia Yaxiong,Cui Shangjin. 2021

[17]The preclinical inhibitor GS441524 in combination with GC376 efficaciously inhibited the proliferation of SARS-CoV-2 in the mouse respiratory tract. Yuejun Shi,Lei Shuai,Zhiyuan Wen,Chong Wang,Yuanyuan Yan,Zhe Jiao,Fenglin Guo,Zhen F. Fu,Huanchun Chen,Zhigao Bu,Guiqing Peng. 2021

[18]Product of natural evolution (SARS, MERS, and SARS-CoV-2); deadly diseases, from SARS to SARS-CoV-2. Mohamad Hesam Shahrajabian,Wenli Sun,Qi Cheng. 2021

[19]The Deltacron conundrum: Its origin and potential health risks. Farheen S., Araf Y., Tang Y.-D., Zheng C.. 2022

[20]Traditional herbal medicines to overcome stress, anxiety and improve mental health in outbreaks of human coronaviruses. Mohamad H. Shahrajabian,Wenli Sun,Ali Soleymani,Qi Cheng. 2021

作者其他论文 更多>>