数字农科院2.0

Toxoplasma gondii ROP5 Enhances Type I IFN Responses by Promoting Ubiquitination of STING

文献类型： 外文期刊

作者： Qi Wang Jin;Ting Yu;Ming Pan;Yi Min Fan;Ceng Ceng Ge;Xiao Bing He;Jing Zhi Gong;Jian Ping Tao;Bao Quan Fu;Zhi Zhong Jing;Si Yang Huang

作者机构：

关键词： cGAS-STING pathway;ROP5;Toxoplasma gondii;ubiquitination

期刊名称： International Journal of Molecular Sciences

ISSN： 1661-6596

年卷期： 2024 年 25 卷 20 期

页码：

收录情况： SCIE（2024版）

摘要： Toxoplasma gondii is a widely spread opportunistic pathogen that can infect nearly all warm-blooded vertebrates and cause serious toxoplasmosis in immunosuppressed animals and patients. However, the relationship between the host’s innate immune system and effector proteins is poorly understood, particularly with regard to how effectors antagonize cGAS-STING signaling during T. gondii infection. In this study, the ROP5 from the PRU strain of T. gondii was found to promote cGAS-STING-mediated immune responses. Mechanistically, ROP5 interacted with STING through predicted domain 2 and modulated cGAS-STING signaling in a predicted domain 3-dependent manner. Additionally, ROP5 strengthened cGAS-STING signaling by enhancing the K63-linked ubiquitination of STING. Consistently, ROP5 deficient PRU (PRUΔROP5) induced fewer type I IFN-related immune responses and replicated faster than the parental strain in RAW264.7 cells. Taken together, this study provides new insights into the mechanism by which ROP5 regulates T. gondii infection and provides new clues for strategies to prevent and control toxoplasmosis.

分类号：

  • 相关文献

[1]DNA vaccination with genes encoding Toxoplasma gondii antigens ROP5 and GRA15 induces protective immunity against toxoplasmosis in Kunming mice. Chen, Jia,Li, Zhong-Yuan,Huang, Si-Yang,Zhou, Dong-Hui,Zhu, Xing-Quan,Li, Zhong-Yuan,Zhu, Xing-Quan,Petersen, Eskild,Zhu, Xing-Quan. 2015

[2]弓形虫TR与ROP5双基因缺失株的构建及其生物学功能研究. 耿小玲,李瑞芳,徐卫兵,杜晶莹,张曼玉,孙卿,蒋蔚,米荣升,陈兆国,王权. 2025

[3]Stability and localization of 14-3-3 proteins are involved in salt tolerance in Arabidopsis. Tan, Tinghong,Cai, Jingqing,Zhan, Erbao,Zhou, Huapeng,Tan, Tinghong,Cai, Jingqing,Zhan, Erbao,Zhou, Huapeng,Yang, Yongqing,Guo, Yan,Zhao, Jinfeng.

[4]Overexpression of soybean ubiquitin-conjugating enzyme gene GmUBC2 confers enhanced drought and salt tolerance through modulating abiotic stress-responsive gene expression in Arabidopsis. Zhou, Guo-An,Chang, Ru-Zhen,Qiu, Li-Juan.

[5]Nitrogen Limitation Adaptation (NLA) is involved in source-to-sink remobilization of nitrate by mediating the degradation of NRT1.7 in Arabidopsis. Liu, Wenwen,Sun, Qing,Wang, Kai,Du, Qingguo,Li, Wen-Xue.

[6]Tobacco RING E3 Ligase NtRFP1 Mediates Ubiquitination and Proteasomal Degradation of a Geminivirus-Encoded beta C1. Hu, Tao,Bao, Min,Cao, Linge,Song, Fengmin,Zhou, Xueping,Bao, Min,Zhou, Xueping,Zhang, Huawei,Xie, Qi,Shen, Qingtang. 2016

[7]A molecular framework underlying low-nitrogen-induced early leaf senescence in Arabidopsis thaliana. Hongmei Fan,Shuxuan Quan,Qing Ye,Lei Zhang,Wei Liu,Ning Zhu,Xiaoqi Zhang,Wenyuan Ruan,Keke Yi,Nigel M. Crawford,Yong Wang. 2023

[8]GhXB38D represses cotton fibre elongation through ubiquitination of ethylene biosynthesis enzymes GhACS4 and GhACO1. Song, Qingwei,Gao, Wanting,Du, Chuanhui,Sun, Wenjie,Wang, Jin,Zuo, Kaijing. 2023

[9]Crystal structure of rice APIP6 reveals a new dimerization mode of RING-type E3 ligases that facilities the construction of its working model. Yangyang Zheng,Xin Zhang,Yang Liu,Tongtong Zhu,Xuefeng Wu,Yuese Ning,Junfeng Liu,Dongli Wang. 2023

[10]Ubiquitination on Lysine 247 of Newcastle Disease Virus Matrix Protein Enhances Viral Replication and Virulence by Driving Nuclear-Cytoplasmic Trafficking. Tingyu Peng,Xusheng Qiu,Lei Tan,Shengqing Yu,Binghuan Yang,Jun Dai,Xiaowen Liu,Yingjie Sun,Cuiping Song,Weiwei Liu,Chunchun Meng,Ying Liao,Weifeng Yuan,Tao Ren,Xiufan Liu,Chan Ding. 2022

[11]Exploring the diversity of plant proteome. Yanmei Chen,Yi Wang,Jun Yang,Wenbin Zhou,Shaojun Dai. 2021

[12]The E3 ubiquitin ligase DESYNAPSIS1 regulates synapsis and recombination in rice meiosis. Lijun Ren,Tingting Zhao,Yangzi Zhao,Guijie Du,Shuying Yang,Na Mu,Ding Tang,Yi Shen,Yafei Li,Zhukuan Cheng. 2021

[13]A VQ-motif-containing protein fine-tunes rice immunity and growth by a hierarchical regulatory mechanism. Hao Z.,Tian J.,Fang H.,Fang L.,Xu X.,He F.,Li S.,Xie W.,Du Q.,You X.,Wang D.,Chen Q.,Wang R.,Zuo S.,Yuan M.,Wang G.-L.,Xia L.,Ning Y.. 2022

[14]Ubiquitylome study reveals the regulatory effect of α-lipoic acid on ubiquitination of key proteins in tryptophan metabolism pathway of pig liver. Jie Gao,Yanjun Cui,Weiguang Bao,Yue Hao,Xiangshu Piao,Xianhong Gu. 2023

[15]GhSINA1, a SEVEN in ABSENTIA ubiquitin ligase, negatively regulates fiber development in Upland cotton. Xiao Qing Yang,Wei Li,Zhong Ying Ren,Jun Jie Zhao,Xin Yang Li,Xing Xing Wang,Xiao Yu Pei,Yan Gai Liu,Kun Lun He,Fei Zhang,Xiong Feng Ma,Dai Gang Yang. 2023

[16]Genome-Wide Identification and Analysis of Ariadne Gene Family Reveal Its Genetic Effects on Agronomic Traits of Brassica napus. Wahid, Sumbal,Xie, Meili,Sarfraz, Sehrish,Liu, Jie,Zhao, Chuanji,Bai, Zetao,Tong, Chaobo,Cheng, Xiaohui,Gao, Feng,Liu, Shengyi. 2022

[17]African Swine Fever Virus MGF360-14L Negatively Regulates Type I Interferon Signaling by Targeting IRF3. Yang Wang,Shuai Cui,Ting Xin,Xixi Wang,Hainan Yu,Shiyu Chen,Yajun Jiang,Xintao Gao,Yitong Jiang,Xiaoyu Guo,Hong Jia,Hongfei Zhu. 2022

[18]The Analysis of the Ubiquitylomic Responses to Streptococcus agalactiae Infection in Bovine Mammary Gland Epithelial Cells. Tong J.,Ji X.,Zhang H.,Xiong B.,Cui D.,Jiang L.. 2022

[19]An ORFeome of rice E3 ubiquitin ligases for global analysis of the ubiquitination interactome. Ruyi Wang,Xiaoman You,Chongyang Zhang,Hong Fang,Min Wang,Fan Zhang,Houxiang Kang,Xiao Xu,Zheng Liu,Jiyang Wang,Qingzhen Zhao,Xuli Wang,Zeyun Hao,Feng He,Hui Tao,Debao Wang,Jisong Wang,Liang Fang,Mengchao Qin,Tianxiao Zhao,Pingping Zhan. 2022

[20]How Many Faces Does the Plant U-Box E3 Ligase Have?. Xinguo Mao,Chunmei Yu,Long Li,Min Wang,Lili Yang,Yining Zhang,Yanfei Zhang,Jingyi Wang,Chaonan Li,Matthew Paul Reynolds,Ruilian Jing. 2022

作者其他论文 更多>>