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Infection of mouse bone marrow-derived immature dendritic cells with classical swine fever virus C-strain promotes cells maturation and lymphocyte proliferation

文献类型： 外文期刊

作者： Zheng, Fu-Ying;Qiu, Chang-Qing;Jia, Huai-Jie;Chen, Guo-Hua;Zeng, Shuang;He, Xiao-Bing;Fang, Yong-Xiang;Lin, Guo-Zhen;Jing, Zhi-Zhong

作者机构：

关键词： Classical swine fever virus C-strain;Classical swine fever virus GSLZ strain;Cytokine;Dendritic cells;Maturation;Stimulation index

期刊名称： RESEARCH IN VETERINARY SCIENCE

ISSN： 0034-5288

年卷期： 2013 年 95 卷 3 期

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收录情况： SCI

摘要： In this study, the interactions of classical swine fever virus (CSFV) C-strain and the virulent GSLZ strain with mouse bone marrow-derived immature dendritic cells (BM-imDCs) were investigated for the first time. Both the C-strain and the virulent GSLZ strain could effectively infect and replicate in mouse BM-imDCs. C-strain-infected BM-imDCs showed a greatly enhanced degree of maturation, and could effectively promote the expansion and proliferation of allogeneic naive T cells. The C-strain induced a stronger Th1 response. Infection with the virulent GSLZ strain had no obvious influence on cell maturation or lymphocyte proliferation, and failed to induce any obvious immune response. The results of this study provided initial information for research of the immunologic mechanisms of CSFV using mouse DCs as the model cells. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.

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