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Interleukin 10 Suppresses the Function of Mouse Bone Marrow-Derived Dendritic Cells Infected with Classical Swine Fever Virus C-Strain

文献类型： 外文期刊

作者： Zheng, Fu-Ying;Lin, Guo-Zhen;Jing, Zhi-Zhong

作者机构：

关键词： Classical swine fever virus (CSFV) C-strain;Dendritic cells (DCs);Interleukin (IL)-10

期刊名称： PAKISTAN VETERINARY JOURNAL

ISSN： 0253-8318

年卷期： 2013 年 33 卷 3 期

页码：

收录情况： SCI

摘要： Interleukin (IL)-10 inhibits the functions of antigen-presenting cells (APCs), including dendritic cells (DCs), however, the precise mechanism of action of IL-10 has not been fully elucidated. In this work, the effects of IL-10 on classical swine fever virus (CSFV) C-strain-infected mouse bone marrow-derived immature DCs (BM-imDCs) were studied. Additional IL-10 suppressed the maturation of the infected BM-imDCs by down-regulating the expression levels of the surface molecules CD80, CD86 and major histocompatibility complex (MHC) classII, while the autocrine IL-10 had no significant effect on the maturation status of the cells. Both additional and autocrine IL-10 markedly inhibited the secretion production of IL-12P40 derived from the BM-imDCs infected with the C-strain, and reduced the capacity of DCs to promote allogeneic naive T cell proliferation. These results showed that IL-10 may play an important role in the DCs-dependent immune response induced by CSFV C-strain. (C) 2013 PVJ. All rights reserved

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